Role of T198 modification in the regulation of p27(Kip1) protein stability and function.

ABSTRACT: The tumor suppressor gene p27(Kip1) plays a fundamental role in human cancer progression. Its expression and/or functions are altered in almost all the different tumor histotype analyzed so far. Recently, it has been demonstrated that the tumor suppression function of p27 resides not only in the ability to inhibit Cyclins/CDKs complexes through its N-terminal domain but also in the capacity to modulate cell motility through its C-terminal portion. Particular interest has been raised by the last amino-acid, (Threonine 198) in the regulation of both protein stability and cell motility.Here, we describe that the presence of Threonine in position 198 is of primary importance for the regulation of the protein stability and for the control of cell motility. However, while the control of cell mot

SUBMITTER: Schiappacassi M 

PROVIDER: S-EPMC3056717 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature