Reduction of cross-reactive carbohydrate determinants in plant foodstuff: elucidation of clinical relevance and implications for allergy diagnosis.

ABSTRACT:

Background

A longstanding debate in allergy is whether or not specific immunoglobulin-E antibodies (sIgE), recognizing cross-reactive carbohydrate determinants (CCD), are able to elicit clinical symptoms. In pollen and food allergy, ≥20% of patients display in-vitro CCD reactivity based on presence of α1,3-fucose and/or β1,2-xylose residues on N-glycans of plant (xylose/fucose) and insect (fucose) glycoproteins. Because the allergenicity of tomato glycoallergen Lyc e 2 was ascribed to N-glycan chains alone, this study aimed at evaluating clinical relevance of CCD-reduced foodstuff in patients with carbohydrate-specific IgE (CCD-sIgE).

Methodology/principal findings

Tomato and/or potato plants with stable reduction of Lyc e 2 (tomato) or CCD formation in general were obtained

SUBMITTER: Kaulfurst-Soboll H 

PROVIDER: S-EPMC3056789 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature