Alteration of gene expression by alcohol exposure at early neurulation.

ABSTRACT:

Background

We have previously demonstrated that alcohol exposure at early neurulation induces growth retardation, neural tube abnormalities, and alteration of DNA methylation. To explore the global gene expression changes which may underline these developmental defects, microarray analyses were performed in a whole embryo mouse culture model that allows control over alcohol and embryonic variables.

Result

Alcohol caused teratogenesis in brain, heart, forelimb, and optic vesicle; a subset of the embryos also showed cranial neural tube defects. In microarray analysis (accession number GSM9545), adopting hypothesis-driven Gene Set Enrichment Analysis (GSEA) informatics and intersection analysis of two independent experiments, we found that there was a collective reduction in ex

SUBMITTER: Zhou FC 

PROVIDER: S-EPMC3056799 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature