Effect of population structure corrections on the results of association mapping tests in complex maize diversity panels.

ABSTRACT: Association mapping of sequence polymorphisms underlying the phenotypic variability of quantitative agronomical traits is now a widely used method in plant genetics. However, due to the common presence of a complex genetic structure within the plant diversity panels, spurious associations are expected to be highly frequent. Several methods have thus been suggested to control for panel structure. They mainly rely on ad hoc criteria for selecting the number of ancestral groups; which is often not evident for the complex panels that are commonly used in maize. It was thus necessary to evaluate the effect of the selected structure models on the association mapping results. A real maize data set (342 maize inbred lines and 12,000 SNPs) was used for this study. The panel structure was estimated

SUBMITTER: Mezmouk S 

PROVIDER: S-EPMC3057001 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature