Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy.

ABSTRACT:

Objective

To describe the natural history, clinical, neurophysiological, and histological features, and outcomes of diabetic patients presenting with acute painful neuropathy associated with glycemic control, also referred to as insulin neuritis.

Methods

Sixteen subjects presenting with acute painful neuropathy had neurological and retinal examinations, laboratory studies, autonomic testing, and pain assessments over 18 months. Eight subjects had skin biopsies for evaluation of intraepidermal nerve fiber density.

Results

All subjects developed severe pain within 8 weeks of intensive glucose control. There was a high prevalence of autonomic cardiovascular, gastrointestinal, genitourinary, and sudomotor symptoms in all subjects. Orthostatic hypotension and parasympathet

SUBMITTER: Gibbons CH 

PROVIDER: S-EPMC3057039 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature