A mechanistic design principle for protein tyrosine kinase sensors: application to a validated cancer target.

ABSTRACT: A new mechanistic principle for reporting the phosphorylation of tyrosine is described, which should prove applicable to even the most fastidious of protein tyrosine kinases, as demonstrated by the acquisition of a fluorescent sensor for the extraordinarily demanding anaplastic lymphoma kinase.

SUBMITTER: Wakata A 

PROVIDER: S-EPMC3057043 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature