Self-reported ethnicity, genetic structure and the impact of population stratification in a multiethnic study.

ABSTRACT: It is well-known that population substructure may lead to confounding in case-control association studies. Here, we examined genetic structure in a large racially and ethnically diverse sample consisting of five ethnic groups of the Multiethnic Cohort study (African Americans, Japanese Americans, Latinos, European Americans and Native Hawaiians) using 2,509 SNPs distributed across the genome. Principal component analysis on 6,213 study participants, 18 Native Americans and 11 HapMap III populations revealed four important principal components (PCs): the first two separated Asians, Europeans and Africans, and the third and fourth corresponded to Native American and Native Hawaiian (Polynesian) ancestry, respectively. Individual ethnic composition derived from self-reported parental informat

SUBMITTER: Wang H 

PROVIDER: S-EPMC3057055 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature