Cytomegalovirus retinitis and the acquired immunodeficiency syndrome--bench to bedside: LXVII Edward Jackson Memorial Lecture.

ABSTRACT:

Purpose

To update information on cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS) and to integrate information on its pathogenesis and clinical outcomes.

Design

Literature review.

Methods

Selected articles from the medical literature, particularly large epidemiologic studies, including the Johns Hopkins Cytomegalovirus Retinitis Cohort Study, the Longitudinal Study of the Ocular Complications of AIDS, and the Cytomegalovirus Retinitis and Viral Resistance Study, were reviewed. Clinical information is discussed in light of knowledge on CMV, its pathogenesis, and its interactions with human immunodeficiency virus (HIV).

Results

Cytomegalovirus uses several mechanisms to evade the immune system and establish latent infecti

SUBMITTER: Jabs DA 

PROVIDER: S-EPMC3057105 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature