Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma.

ABSTRACT:

Background & aims

Mutations in TP53, a tumor suppressor gene, are associated with prognosis of many cancers. However, the prognostic values of TP53 mutation sites are not known for patients with hepatocellular carcinoma (HCC) because of heterogeneity in their geographic and etiologic backgrounds.

Methods

TP53 mutations were investigated in a total of 409 HCC patients, including Chinese (n = 336) and white (n = 73) patients, using the direct sequencing method.

Results

A total of 125 TP53 mutations were found in Chinese patients with HCC (37.2%). HCC patients with TP53 mutations had a shorter overall survival time compared with patients with wild-type TP53 (hazard ratio [HR], 1.86; 95% confidence interval [CI]: 1.37-2.52; P < .001). The hot spot mutations R249S and V157

SUBMITTER: Woo HG 

PROVIDER: S-EPMC3057345 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature