The HWE histidine kinases, a new family of bacterial two-component sensor kinases with potentially diverse roles in environmental signaling.

ABSTRACT: Two-component signal transduction pathways play a major role in the response of bacteria to external cues. These pathways are initiated by large collection of histidine kinases (HKs) containing a sensor domain that perceives the environmental signal followed by an HK domain that triggers a histidine-aspartate phosphorelay. Previous phylogenetic analyses identified 11 major families of two-component HKs by comparing signature motifs within the HK domain. Here we describe a new family with homology to Agrobacterium tumefaciens BphP2, an HK first discovered by the presence of a phytochrome sensor domain involved in light perception. Members of this sensor HK family differ from most others by the absence of a recognizable F box and the presence of several uniquely conserved residues, including

SUBMITTER: Karniol B 

PROVIDER: S-EPMC305753 | biostudies-literature | 2004 Jan

REPOSITORIES: biostudies-literature