Latent structure and factorial invariance of a neuropsychological test battery for the study of preclinical Alzheimer's disease.

ABSTRACT:

Objective

To examine the latent structure of a test battery currently being used in a longitudinal study of asymptomatic middle-aged adults with a parental history of Alzheimer's disease (AD) and test the invariance of the factor solution across subgroups defined by selected demographic variables and known genetic risk factors for AD.

Method

An exploratory factor analysis (EFA) and a sequence of confirmatory factor analyses (CFA) were conducted on 24 neuropsychological measures selected to provide a comprehensive estimate of cognitive abilities most likely to be affected in preclinical AD. Once the underlying latent model was defined and the structural validity established through model comparisons, a multigroup confirmatory factor analysis model was used to test for factori

SUBMITTER: Dowling NM 

PROVIDER: S-EPMC3057903 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature