Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.

ABSTRACT:

Importance of the field

Antipsychotic drug is the mainstay of treatment for schizophrenia, and there are large inter-individual differences in clinical response and side effects. Pharmacogenetics provides a valuable tool to fulfill the promise of personalized medicine by tailoring treatment based on one's genetic markers.

Areas covered in this review

This article reviews the pharmacogenetic literature from early 1990s to 2010, focusing on two aspects of drug action: pharmacokinetics and pharmacodynamics. Genetic variants in the neurotransmitter receptors including dopamine and 5-HT and metabolic pathways of drugs including CYP2D6 and COMT were discussed in association with clinical drug response and side effects.

What the reader will gain

Readers are expected to learn

SUBMITTER: Zhang JP 

PROVIDER: S-EPMC3057913 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature