Immunoglobulin E antibody reactivity to bacterial antigens in atopic dermatitis patients.

ABSTRACT:

Background

Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting up to 20% children and 9% adults world-wide. AD patients are often sensitized against a broad variety of allergens and more than 90% of them suffer from skin superinfections with Staphylococcus aureus.

Objective

In this study, we searched for the presence of specific IgE antibodies against S. aureus and Escherichia coli antigens in AD patients.

Methods

Sera from AD patients (n=79), patients suffering only from allergic rhinoconjunctivitis (n=41) or allergic asthma (n=37) were tested for IgE reactivity to nitrocellulose-blotted S. aureus, E. coli and gut bacterial antigens. IgE-reactive bacterial antigens were affinity purified and identified by mass spectrometry.

Results

More tha

SUBMITTER: Reginald K 

PROVIDER: S-EPMC3057935 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature