Joint QTL linkage mapping for multiple-cross mating design sharing one common parent.

ABSTRACT:

Background

Nested association mapping (NAM) is a novel genetic mating design that combines the advantages of linkage analysis and association mapping. This design provides opportunities to study the inheritance of complex traits, but also requires more advanced statistical methods. In this paper, we present the detailed algorithm of a QTL linkage mapping method suitable for genetic populations derived from NAM designs. This method is called joint inclusive composite interval mapping (JICIM). Simulations were designed on the detected QTL in a maize NAM population and an Arabidopsis NAM population so as to evaluate the efficiency of the NAM design and the JICIM method.

Principal findings

Fifty-two QTL were identified in the maize population, explaining 89% of the phenotypic va

SUBMITTER: Li H 

PROVIDER: S-EPMC3057965 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature