Assessment of human papillomavirus in lung tumor tissue.

ABSTRACT:

Background

Lung cancer kills more than 1 million people worldwide each year. Whereas several human papillomavirus (HPV)-associated cancers have been identified, the role of HPV in lung carcinogenesis remains controversial.

Methods

We selected 450 lung cancer patients from an Italian population-based case-control study, the Environment and Genetics in Lung Cancer Etiology. These patients were selected from those with an adequate number of unstained tissue sections and included all those who had never smoked and a random sample of the remaining patients. We used real-time polymerase chain reaction (PCR) to test specimens from these patients for HPV DNA, specifically for E6 gene sequences from HPV16 and E7 gene sequences from HPV18. We also tested a subset of 92 specimens from

SUBMITTER: Koshiol J 

PROVIDER: S-EPMC3057981 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature