A modified scoring system to describe gross pathology in the rabbit model of tuberculosis.

ABSTRACT:

Background

The rabbit model is an ideal means to study the pathogenesis of tuberculosis due to its semblance to the disease in humans. We have previously described the results using a bronchoscopic route of infection with live bacilli as a reliable means of generating lung cavities in sensitized rabbits. The role of sensitization in the development of disease outcomes has been well established in several animal models. We have described here the varying gross pathology that result from lack of sensitization with heat-killed M. bovis prior to high-dose bronchoscopic infection with live bacilli.

Results

Rabbits lacking sensitization did not generate lung cavities, but instead formed solely a tuberculoid pneumonia that replaced the normal lung parenchyma in the area of infectio

SUBMITTER: Jassal MS 

PROVIDER: S-EPMC3058006 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature