Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis.

ABSTRACT:

Background

Coronary artery disease (CAD) shares common risk factors with type 2 diabetes (T2DM). Variations in the transcription factor 7-like 2 (TCF7L2) gene, particularly rs7903146, increase T2DM risk. Potential links between genetic variants of the TCF7L2 locus and coronary atherosclerosis are uncertain. We therefore investigated the association between TCF7L2 polymorphisms and angiographically determined CAD in diabetic and non-diabetic patients.

Methodology/principal findings

We genotyped TCF7L2 variants rs7903146, rs12255372, and rs11196205 in a cross-sectional study including 1,650 consecutive patients undergoing coronary angiography for the evaluation of established or suspected stable CAD. Significant CAD was diagnosed in the presence of coronary stenoses ≥50%. Vari

SUBMITTER: Muendlein A 

PROVIDER: S-EPMC3058059 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature