Proteasome inhibition alleviates prolonged moderate compression-induced muscle pathology.

ABSTRACT:

Background

The molecular mechanism initiating deep pressure ulcer remains to be elucidated. The present study tested the hypothesis that the ubiquitin proteasome system is involved in the signalling mechanism in pressure-induced deep tissue injury.

Methods

Adult Sprague Dawley rats were subjected to an experimental compression model to induce deep tissue injury. The tibialis region of the right hind limb was subjected to 100 mmHg of static pressure for six hours on each of two consecutive days. The compression pressure was continuously monitored by a three-axial force transducer within the compression indentor. The left hind limb served as the intra-animal control. Muscle tissues underneath the compressed region were collected and used for analyses.

Results

Our result

SUBMITTER: Siu PM 

PROVIDER: S-EPMC3058073 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature