Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.

ABSTRACT: Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid thought to be dysregulated in a variety of disease conditions. In this review, we discuss the roles of S1P in cancer and in wet age-related macular degeneration. We also explore potential treatment strategies for these disorders, including the utility of anti-S1P antibodies acting as molecular sponges to neutralize dysregulated S1P in relevant tissues.

SUBMITTER: Sabbadini RA 

PROVIDER: S-EPMC3058156 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature