Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children.

ABSTRACT:

Background

Exhaled nitric oxide (FeNO) is a biomarker of airway inflammation. In the nitric oxide (NO) synthesis pathway, nitric oxide synthases (encoded by NOS1, NOS2A, and NOS3) and arginases (encoded by ARG1 and ARG2) compete for L-arginine. Although FeNO levels are higher in children with asthma/allergy, influence of these conditions on the relationships between variations in these genes and FeNO remains unknown. The aims of the study were to evaluate the role of genetic variations in nitric oxide synthases and arginases on FeNO in children and to assess the influence of asthma and respiratory allergy on these genetic associations.

Methods

Among children (6-11 years) who participated in the southern California Children's Health Study, variations in these five genetic loc

SUBMITTER: Salam MT 

PROVIDER: S-EPMC3058253 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature