Variants at APOE influence risk of deep and lobar intracerebral hemorrhage.

ABSTRACT:

Objective

Prior studies investigating the association between APOE alleles ε2/ε4 and risk of intracerebral hemorrhage (ICH) have been inconsistent and limited to small sample sizes, and did not account for confounding by population stratification or determine which genetic risk model was best applied.

Methods

We performed a large-scale genetic association study of 2189 ICH cases and 4041 controls from 7 cohorts, which were analyzed using additive models for ε2 and ε4. Results were subsequently meta-analyzed using a random effects model. A proportion of the individuals (322 cases, 357 controls) had available genome-wide data to adjust for population stratification.

Results

Alleles ε2 and ε4 were associated with lobar ICH at genome-wide significance levels (odds ratio [

SUBMITTER: Biffi A 

PROVIDER: S-EPMC3058266 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature