Improved prognosis for older adolescents with acute lymphoblastic leukemia.

ABSTRACT:

Purpose

The prognosis for older adolescents and young adults with acute lymphoblastic leukemia (ALL) has been historically much worse than that for younger patients. We reviewed the outcome of older adolescents (age 15 to 18 years) treated in four consecutive Total Therapy studies to determine if recent improved treatment extended to this high-risk group.

Patients and methods

Between 1991 and 2007, 963 pediatric patients, including 89 older adolescents, were enrolled on Total Therapy studies XIIIA, XIIIB, XIV, and XV. In the first three studies, treatment selection was based on presenting clinical features and leukemic cell genetics. In study XV, the level of residual disease was used to guide treatment, which featured intensive methotrexate, glucocorticoid, vincristine, and

SUBMITTER: Pui CH 

PROVIDER: S-EPMC3058285 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature