Analysis of distinct short and prolonged components in rebound spiking of deep cerebellar nucleus neurons.

ABSTRACT: Deep cerebellar nucleus (DCN) neurons show pronounced post-hyperpolarization rebound burst behavior, which may contribute significantly to responses to strong inhibitory inputs from cerebellar cortical Purkinje cells. Thus, rebound behavior could importantly shape the output from the cerebellum. We used whole-cell recordings in brain slices to characterize DCN rebound properties and their dependence on hyperpolarization duration and depth. We found that DCN rebounds showed distinct fast and prolonged components, with different stimulus dependence and different underlying currents. The initial depolarization leading into rebound spiking was carried by hyperpolarization-activated cyclic nucleotide-gated current, and variable expression of this current could lead to a control of rebound laten

SUBMITTER: Sangrey T 

PROVIDER: S-EPMC3058674 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature