Ontology highlight
ABSTRACT:
SUBMITTER: Kutty G
PROVIDER: S-EPMC3058675 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Kutty Geetha G Achaz Guillaume G Maldarelli Frank F Varma Ashok A Shroff Robert R Becker Steven S Fantoni Giovanna G Kovacs Joseph A JA
The Journal of infectious diseases 20101104 12
The life cycle of Pneumocystis, which causes life-threatening pneumonia in immunosuppressed patients, remains poorly defined. In the present study, we have identified and characterized an orthologue of dmc1, a gene specific for meiotic recombination in yeast, in 3 species of Pneumocystis. dmc1 is a single-copy gene that is transcribed as ∼1.2-kb messenger RNA, which encodes a protein of 336-337 amino acids. Pneumocystis Dmc1 was 61%-70% identical to those from yeast. Confocal microscopy results ...[more]