Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation.

ABSTRACT:

Background

Airway tolerance is critical for protecting the lung from inflammatory disease driven by allergens. However, factors that disrupt tolerance processes and then lead to susceptibility to developing allergic asthma remain elusive.

Objective

To investigate whether recognition of bacterial microbial-associated molecular patterns in the lung may result in susceptibility to developing allergic reactions, and to understand the molecular mechanisms by which such triggers block natural tolerance.

Methods

Ligands of intracellular microbial-associated molecular pattern recognition receptors-the nucleotide-binding oligomerization domain (Nod)-like receptors, Nod1 and Nod2-were given intranasally with antigen, and their ability to modulate airway tolerance was analyzed.<

SUBMITTER: Duan W 

PROVIDER: S-EPMC3058679 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature