Texture analysis of the epidermis based on fast Fourier transformation in Sjogren-Larsson syndrome.

ABSTRACT:

Objective

To investigate whether image analysis of routine hematoxylin-eosin (H-E) skin sections using fast Fourier transformation (FFT) could detect structural alterations in patients with Sjögren-Larsson syndrome (SLS) diagnosed by molecular biology.

Study design

Skin punch biopsies of 9 patients with SLS and 17 healthy volunteers were obtained. Digital images of routine histologic sections were taken, and their gray scale luminance was analyzed by FFT. The inertia values were determined for different ranges of the spatial frequencies in the vertical and horizontal direction. To get an estimation of anisotropy, we calculated the resultant vector of the designated frequency ranges.

Results

In the prickle cell layer, SLS patients showed more intense amplitudes in spat

SUBMITTER: Auada MP 

PROVIDER: S-EPMC3058945 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature