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Surface modification of polymeric micelles by strain-promoted alkyne-azide cycloadditions.

ABSTRACT: Organomicelles modified by surface dibenzylcyclooctyne moieties can conveniently be functionalized by strain-promoted alkyne-azide cycloadditions. The ligation approach is highly efficient, does not require toxic reagents and is compatible with a wide variety of functional modules. Interactions of proteins with surface ligands of the micelles have been studied by AFM, which revealed that it leads to disassembly of the particles thereby providing a mechanism for triggered drug release.

SUBMITTER: Guo J 

PROVIDER: S-EPMC3059085 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Surface modification of polymeric micelles by strain-promoted alkyne-azide cycloadditions.

Guo Jun J   Chen Guojun G   Ning Xinghai X   Wolfert Margreet A MA   Li Xiuru X   Xu Bingqian B   Boons Geert-Jan GJ  

Chemistry (Weinheim an der Bergstrasse, Germany) 20101201 45

Organomicelles modified by surface dibenzylcyclooctyne moieties can conveniently be functionalized by strain-promoted alkyne-azide cycloadditions. The ligation approach is highly efficient, does not require toxic reagents and is compatible with a wide variety of functional modules. Interactions of proteins with surface ligands of the micelles have been studied by AFM, which revealed that it leads to disassembly of the particles thereby providing a mechanism for triggered drug release. ...[more]

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