Alveolar macrophage gene expression is altered in the setting of alcohol use disorders.

ABSTRACT:

Background

Alcohol use disorders (AUDs) are associated with an increased susceptibility to a variety of common and devastating pulmonary diseases including community- and hospital-acquired pneumonias, as well as the acute respiratory distress syndrome (ARDS). Alveolar macrophages play an important role in preventing the development of these disorders through maintaining lung sterility and resolving lung inflammation. Although alcohol exposure has been associated with aberrant alveolar macrophage function in animal models, the clinical relevance of these observations in humans is not established. Therefore, we sought to determine the effects of AUDs on human alveolar macrophage gene expression.

Methods

Whole genome microarray analysis was performed on alveolar macrophages obt

SUBMITTER: Burnham EL 

PROVIDER: S-EPMC3059108 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature