Loss of sarcolemmal nNOS is common in acquired and inherited neuromuscular disorders.

ABSTRACT:

Objective

Neuronal nitric oxide synthase (nNOS), normally expressed at the sarcolemmal membrane, is known to be mislocalized to the sarcoplasm in several forms of muscular dystrophy. Our objectives were to characterize further the range of patients manifesting aberrant nNOS sarcolemmal immunolocalization and to study nNOS localization in animal models of nondystrophic myopathy.

Methods

We carried out a retrospective cross-sectional study. We performed immunofluorescent staining for nNOS on biopsy specimens from 161 patients with acquired and nondystrophin inherited neuromuscular conditions. The localization of sarcolemmal nNOS correlated with mobility and functional status. Muscle specimens from mouse models of steroid-induced and starvation-related atrophy were studied for

SUBMITTER: Finanger Hedderick EL 

PROVIDER: S-EPMC3059139 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature