Use of ibuprofen and risk of Parkinson disease.

ABSTRACT:

Background

Neuroinflammation may contribute to the pathogenesis of Parkinson disease (PD). Use of nonsteroidal anti-inflammatory drugs (NSAID) in general, and possibly ibuprofen in particular, has been shown to be related to lower PD risk in previous epidemiologic studies.

Methods

We prospectively examined whether use of ibuprofen or other NSAIDs is associated with lower PD risk among 136,197 participants in the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS) free of PD at baseline (1998 for NHS and 2000 for HPFS). NSAIDs use was assessed via questionnaire. Results were combined in a meta-analysis with those of published prospective investigations.

Results

We identified 291 incident PD cases during 6 years of follow-up. Users of ibuprofe

SUBMITTER: Gao X 

PROVIDER: S-EPMC3059148 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature