Cytotoxicity screening of 23 engineered nanomaterials using a test matrix of ten cell lines and three different assays.

ABSTRACT:

Background

Engineered nanomaterials display unique properties that may have impact on human health, and thus require a reliable evaluation of their potential toxicity. Here, we performed a standardized in vitro screening of 23 engineered nanomaterials. We thoroughly characterized the physicochemical properties of the nanomaterials and adapted three classical in vitro toxicity assays to eliminate nanomaterial interference. Nanomaterial toxicity was assessed in ten representative cell lines.

Results

Six nanomaterials induced oxidative cell stress while only a single nanomaterial reduced cellular metabolic activity and none of the particles affected cell viability. Results from heterogeneous and chemically identical particles suggested that surface chemistry, surface coating an

SUBMITTER: Kroll A 

PROVIDER: S-EPMC3059267 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature