Effect of a single dose of pregabalin on herpes zoster pain.

ABSTRACT:

Background

The effect of pregabalin on acute herpes zoster pain has not been previously evaluated.

Methods

In a randomized, double-blind, placebo-controlled, two-session crossover study the effect of a single oral dose of pregabalin (150 mg) on pain and allodynia was evaluated in 8 subjects with herpes zoster.

Results

Over 6 hours of observation, pain decreased by a mean of 33% with pregabalin and 14% with placebo (p < 0.10). Effects on allodynia and SF-MPQ were not significant.

Conclusions

Compared to an earlier study of gabapentin 900 mg for acute zoster pain and allodynia that followed a nearly identical protocol, pregabalin had a similar effect on pain and was well tolerated, with no difference from placebo on sleepiness. Common side effects of light-headed

SUBMITTER: Jensen-Dahm C 

PROVIDER: S-EPMC3059274 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature