Diet folate, DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma.

ABSTRACT:

Background

Folic acid may affect the development of human cancers. However, few studies have evaluated the consumption of diet folate in the prognosis of patients with esophageal squamous cell carcinoma (ESCC).

Methods

One hundred and twenty five ESCC patients underwent esophagectomy between January 2005 and March 2006 in the Yangzhong People's Hospital were recruited and followed up. The effects of diet folate, aberrant DNA methylation of selected genes and methylenetetrahydrofolate reductase (MTHFR) C677T genetic polymorphisms on the prognosis of ESCC were evaluated by using Cox proportional hazard regression models.

Results

Our analysis showed an inverse association between diet folate intake and the risk of death after esophagectomy. The median survival time was 3

SUBMITTER: Lu C 

PROVIDER: S-EPMC3059302 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature