Identification of surface proteins in Enterococcus faecalis V583.

ABSTRACT:

Background

Surface proteins are a key to a deeper understanding of the behaviour of Gram-positive bacteria interacting with the human gastro-intestinal tract. Such proteins contribute to cell wall synthesis and maintenance and are important for interactions between the bacterial cell and the human host. Since they are exposed and may play roles in pathogenicity, surface proteins are interesting targets for drug design.

Results

Using methods based on proteolytic "shaving" of bacterial cells and subsequent mass spectrometry-based protein identification, we have identified surface-located proteins in Enterococcus faecalis V583. In total 69 unique proteins were identified, few of which have been identified and characterized previously. 33 of these proteins are predicted to be cy

SUBMITTER: Bohle LA 

PROVIDER: S-EPMC3059304 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature