Prospective identification and isolation of enteric nervous system progenitors using Sox2.

ABSTRACT: The capacity to identify and isolate lineage-specific progenitor cells from developing and mature tissues would enable the development of cell replacement therapies for disease treatment. The enteric nervous system (ENS) regulates important gut functions, including controlling peristaltic muscular contractions, and consists of interconnected ganglia containing neurons and glial cells. Hirschsprung's disease (HSCR), one of the most common and best understood diseases affecting the ENS, is characterized by absence of enteric ganglia from the distal gut due to defects in gut colonization by neural crest progenitor cells and is an excellent candidate for future cell replacement therapies. Our previous microarray experiments identified the neural progenitor and stem cell marker SRY-related homo

SUBMITTER: Heanue TA 

PROVIDER: S-EPMC3059409 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature