Prostate cancer predisposition loci and risk of metastatic disease and prostate cancer recurrence.

ABSTRACT:

Purpose

Genome-wide association studies (GWAS) have identified multiple novel prostate cancer predisposition loci. Whether these common genetic variants are associated with incident metastatic prostate cancer or with recurrence after surgical treatment for clinically localized prostate cancer is uncertain.

Experimental design

Twelve single nucleotide polymorphisms (SNPs) were selected for study in relation to prostate metastatic cancer and recurrence, based on their genome-wide association with prostate cancer in the Cancer Genetic Markers of Susceptibility (CGEMS). To assess risk for metastatic disease, we compared genotypes for the 12 SNPs by logistic regression of 470 incident metastatic prostate cancer cases and 1,945 controls in 3 case-control studies. To assess the rel

SUBMITTER: Ahn J 

PROVIDER: S-EPMC3059497 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature