Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils.

ABSTRACT:

Background

Mast cells and basophils are key effector cells of IgE-mediated anaphylactic reactions. The Chinese herbal formula, food allergy herbal formula 2 (FAHF-2), protects against peanut anaphylaxis in mice. However, the mechanisms underlying this effect are not fully elucidated.

Objective

To investigate whether FAHF-2 inhibits mast cell/basophil numbers and IgE-mediated activation.

Methods

Mice with peanut allergy (PNA mice) were treated with FAHF-2 intragastrically for 7 weeks and challenged intragastrically with peanut 1 day and 4 weeks posttreatment. Peripheral blood basophil numbers and peritoneal mast cell numbers and FcεRI expression were determined. Direct effects of FAHF-2 on the murine mast cell line MC/9, and effects of 4 fractions and 3 compounds isola

SUBMITTER: Song Y 

PROVIDER: S-EPMC3059770 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature