Genome-wide interaction-based association analysis identified multiple new susceptibility Loci for common diseases.

ABSTRACT: Genome-wide interaction-based association (GWIBA) analysis has the potential to identify novel susceptibility loci. These interaction effects could be missed with the prevailing approaches in genome-wide association studies (GWAS). However, no convincing loci have been discovered exclusively from GWIBA methods, and the intensive computation involved is a major barrier for application. Here, we developed a fast, multi-thread/parallel program named "pair-wise interaction-based association mapping" (PIAM) for exhaustive two-locus searches. With this program, we performed a complete GWIBA analysis on seven diseases with stringent control for false positives, and we validated the results for three of these diseases. We identified one pair-wise interaction between a previously identified locus,

SUBMITTER: Liu Y 

PROVIDER: S-EPMC3060075 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature