Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.

ABSTRACT:

Background

Various cytokines and inflammatory mediators are known to be involved in the pathogenesis of rheumatoid arthritis (RA). We hypothesized that polymorphisms in selected inflammatory response and tissue repair genes contribute to the susceptibility to and severity of RA.

Methods

Polymorphisms in TNFA, IL1B, IL4, IL6, IL8, IL10, PAI1, NOS2a, C1INH, PARP, TLR2 and TLR4 were genotyped in 376 Caucasian RA patients and 463 healthy Caucasian controls using single base extension. Genotype distributions in patients were compared with those in controls. In addition, the association of polymorphisms with the need for anti-TNF-α treatment as a marker of RA severity was assessed.

Results

The IL8 781 CC genotype was associated with early onset of disease. The TNFA -238 G/A

SUBMITTER: Emonts M 

PROVIDER: S-EPMC3060109 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature