A further insight into the sialome of the tropical bont tick, Amblyomma variegatum.

ABSTRACT:

Background

Ticks--vectors of medical and veterinary importance--are themselves also significant pests. Tick salivary proteins are the result of adaptation to blood feeding and contain inhibitors of blood clotting, platelet aggregation, and angiogenesis, as well as vasodilators and immunomodulators. A previous analysis of the sialotranscriptome (from the Greek sialo, saliva) of Amblyomma variegatum is revisited in light of recent advances in tick sialomes and provides a database to perform a proteomic study.

Results

The clusterized data set has been expertly curated in light of recent reviews on tick salivary proteins, identifying many new families of tick-exclusive proteins. A proteome study using salivary gland homogenates identified 19 putative secreted proteins within a t

SUBMITTER: Ribeiro JM 

PROVIDER: S-EPMC3060141 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature