Host iron withholding demands siderophore utilization for Candida glabrata to survive macrophage killing.

ABSTRACT: The fungal pathogen Candida glabrata has risen from an innocuous commensal to a major human pathogen that causes life-threatening infections with an associated mortality rate of up to 50%. The dramatic rise in the number of immunocompromised individuals from HIV infection, tuberculosis, and as a result of immunosuppressive regimens in cancer treatment and transplant interventions have created a new and hitherto unchartered niche for the proliferation of C. glabrata. Iron acquisition is a known microbial virulence determinant and human diseases of iron overload have been found to correlate with increased bacterial burden. Given that more than 2 billion people worldwide suffer from iron deficiency and that iron overload is one of the most common single-gene inherited diseases, it is importan

SUBMITTER: Nevitt T 

PROVIDER: S-EPMC3060170 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature