Augmented rififylin is a risk factor linked to aberrant cardiomyocyte function, short-QT interval and hypertension.

ABSTRACT: Using congenic strains of the Dahl salt-sensitive (S) rat introgressed with genomic segments from the normotensive Lewis rat, a blood pressure quantitative trait locus was previously mapped within 104 kb on chromosome 10. The goal of the current study was to conduct extensive phenotypic studies and to further fine-map this locus. At 14 weeks of age, the blood pressure of the congenic rats fed a low-salt diet was significantly higher by 47 mm Hg (P<0.001) compared with that of the S rat. A time-course study showed that the blood pressure effect was significant from very young ages of 50 to 52 days (13 mm Hg; P<0.01). The congenic strain implanted with electrocardiography transmitters demonstrated shorter-QT intervals and increased heart rate compared with S rats (P<0.01). The average surviv

SUBMITTER: Gopalakrishnan K 

PROVIDER: S-EPMC3060303 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature