EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units.

ABSTRACT: Detection of epistatic interaction between loci has been postulated to provide a more in-depth understanding of the complex biological and biochemical pathways underlying human diseases. Studying the interaction between two loci is the natural progression following traditional and well-established single locus analysis. However, the added costs and time duration required for the computation involved have thus far deterred researchers from pursuing a genome-wide analysis of epistasis. In this paper, we propose a method allowing such analysis to be conducted very rapidly. The method, dubbed EPIBLASTER, is applicable to case-control studies and consists of a two-step process in which the difference in Pearson's correlation coefficients is computed between controls and cases across all possibl

SUBMITTER: Kam-Thong T 

PROVIDER: S-EPMC3060319 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature