Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats.

ABSTRACT: Several studies indicate that adult stem cells may improve the recovery from acute tissue injury. It has been suggested that they may contribute to tissue regeneration by the release of paracrine factors promoting proliferation of tissue resident cells. However, the factors involved remain unknown. In the present study we found that microvesicles (MVs) derived from human liver stem cells (HLSC) induced in vitro proliferation and apoptosis resistance of human and rat hepatocytes. These effects required internalization of MVs in the hepatocytes by an alpha(4)-integrin-dependent mechanism. However, MVs pre-treated with RNase, even if internalized, were unable to induce hepatocyte proliferation and apoptosis resistance, suggesting an RNA-dependent effect. Microarray analysis and quantitative R

SUBMITTER: Herrera MB 

PROVIDER: S-EPMC3060338 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature