A comprehensive Plasmodium falciparum protein interaction map reveals a distinct architecture of a core interactome.

ABSTRACT: We derive a map of protein interactions in the parasite Plasmodium falciparum from conserved interactions in Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, and Escherichia coli and pool them with experimental interaction data. The application of a clique-percolation algorithm allows us to find overlapping clusters, strongly correlated with yeast specific conserved protein complexes. Such clusters contain core activities that govern gene expression, largely dominated by components of protein production and degradation processes as well as RNA metabolism. A critical role of protein hubs in the interactome of P. falciparum is supported by their appearance in multiple clusters and the tendencies of their interactions to reach into many distinct protein clusters. Par

SUBMITTER: Wuchty S 

PROVIDER: S-EPMC3060782 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature