The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells.

ABSTRACT:

Background

Notch and Wnt pathways are key regulators of intestinal homeostasis and alterations in these pathways may lead to the development of colorectal cancer (CRC). In CRC the Apc/β-catenin genes in the Wnt signaling pathway are frequently mutated and active Notch signaling contributes to tumorigenesis by keeping the epithelial cells in a proliferative state. These pathways are simultaneously active in proliferative adenoma cells and a crosstalk between them has previously been suggested in normal development as well as in cancer.

Principal findings

In this study, in silico analysis of putative promoters involved in transcriptional regulation of genes coding for proteins in the Notch signaling pathway revealed several putative LEF-1/TCF sites as potential targets for β-c

SUBMITTER: Ungerback J 

PROVIDER: S-EPMC3060910 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature