ALOX12 polymorphisms are associated with fat mass but not peak bone mineral density in Chinese nuclear families.

ABSTRACT:

Objective

Arachidonate 12-lipoxygenase (ALOX12) is a member of the lipoxygenase superfamily, which catalyzes the incorporation of molecular oxygen into polyunsaturated fatty acids. The products of ALOX12 reactions serve as endogenous ligands for peroxisome proliferator-activated receptor γ (PPARG). The activation of the PPARG pathway in marrow-derived mesenchymal progenitors stimulates adipogenesis and inhibits osteoblastogenesis. Our objective was to determine whether polymorphisms in the ALOX12 gene were associated with variations in peak bone mineral density (BMD) and obesity phenotypes in young Chinese men.

Methods

All six tagging single-nucleotide polymorphisms (SNPs) in the ALOX12 gene were genotyped in a total of 1215 subjects from 400 Chinese nuclear families by alle

SUBMITTER: Xiao WJ 

PROVIDER: S-EPMC3061002 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature