The ATP-binding cassette transporter ABCB6 is induced by arsenic and protects against arsenic cytotoxicity.

ABSTRACT: Arsenic, an environmental carcinogen, remains a major public health problem. Arsenic damages biological systems through multiple mechanisms, including the generation of reactive oxygen species. ABCB6 is an ATP-binding cassette transporter that is highly expressed in cells resistant to arsenic. We have recently demonstrated that ABCB6 expression protects against cellular stressors. In the present study, we evaluated the significance of ABCB6 expression to arsenic toxicity both in mice and in cell culture. We show that sodium arsenite induces ABCB6 expression in a dose-dependent manner both in mice fed sodium arsenite in drinking water and in cells exposed to sodium arsenite in vitro. Arsenite-induced ABCB6 expression was transcriptionally regulated, but this induction was not mediated by th

SUBMITTER: Chavan H 

PROVIDER: S-EPMC3061481 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature