CDCOCA: a statistical method to define complexity dependence of co-occuring chromosomal aberrations.

ABSTRACT:

Background

Copy number alterations (CNA) play a key role in cancer development and progression. Since more than one CNA can be detected in most tumors, frequently co-occurring genetic CNA may point to cooperating cancer related genes. Existing methods for co-occurrence evaluation so far have not considered the overall heterogeneity of CNA per tumor, resulting in a preferential detection of frequent changes with limited specificity for each association due to the high genetic instability of many samples.

Method

We hypothesize that in cancer some linkage-independent CNA may display a non-random co-occurrence, and that these CNA could be of pathogenetic relevance for the respective cancer. We also hypothesize that the statistical relevance of co-occurring CNA may depend on the

SUBMITTER: Kumar N 

PROVIDER: S-EPMC3061884 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature