Tissue distribution and pharmacokinetics of stable polyacrylamide nanoparticles following intravenous injection in the rat.

ABSTRACT: A variety of polymer nanoparticles (NP) are under development for imaging and therapeutic use. However, little is known about their behavior. This study examined pharmacokinetics, distribution and elimination of stable polyacrylamide (PAA) nanoparticles (~31 nm average diameter). PAA NPs and polyethylene glycol-coated PAA NPs were injected into the tail veins of healthy male rats. Blood, tissues and excreta were collected at times ranging from 5 min to 120 h and their radioactive content was quantified. A mathematical model was then applied to analyze the distribution dynamics of both NPs. Elimination from the blood could be accounted for by a quick but finite relocation to the major organs (about 20%, 0.6 to 1.3h half-lives), and a slower distribution to the carcass (about 70%, 35 to 43 h

SUBMITTER: Wenger Y 

PROVIDER: S-EPMC3061931 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature